2014 Fiscal Year Final Research Report
Preparation of polyphosphoesters for controlled bone remodeling
| Project/Area Number |
24500532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Kansai University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ポリリン酸エステル / 開環重合 / 骨リモデリング / 骨芽細胞 / 破骨細胞 / DDS / プロドラッグ |
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| Outline of Final Research Achievements |
Polyphosphoesters are unique polymeric biomaterials because of their biocompatibility, biodegradability and bone affinity. Synthesis of poly(ethylene sodium phosphate) (PEP-Na) was achieved through ring-opening polymerization of 2-methoxy-2-oxo-1,3,2-dioxaphospholane followed by hydrolysis. We investigated the viability and function of human osteoclasts and murine osteoblasts precursors in contact with 100 mg/mL of PEP-Na This did not trigger any significant effect on osteoblast cell viability. In contrast, the polymer effectively reduced the adhesion of human osteoclasts on bone slices at concentration as low as 0.0001 mg/mL. Moreover, the in situ generation of resorption pits was also effectively reduced. This is the first report to demonstrate the possibility of using polyphosphoesters for selective inhibition of osteoclast function and bone resorption. This study indicates that PEP-Na has potential to be used as an effective polymer prodrug for bone therapy.
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| Free Research Field |
生体材料学
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