Noninvasive assessment of left ventricular diastolic function using a Novel myocardial strain imaging index

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500554
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: The University of Tokyo
• Principal Investigator: DAIMON Masao 東京大学, 医学部附属病院, 講師 (80343094)
• Co-Investigator(Kenkyū-buntansha): KAWATA Takayuki 東京大学, 医学部附属病院, 助教 (20532526)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 超音波検査 / 血行動態 / 心不全

Outline of Final Research Achievements

In this study, we aimed to determine whether global strain imaging diastolic index (SIDI) obtained using 2D speckle tracking imaging (2DSI) could be useful for assessing left ventricular (LV) diastolic function. We found that SIDI showed a stronger correlation with NT-pro BNP levels than conventional diastolic indices in hypertensive patients, and that longitudinal SIDI could predict elevated levels and rapid change of LV filling pressure in the clinical settings. Moreover, we reported that SIDI was useful for detecting coronary artery stenosis without a stress test in patients with normal LV wall motion. 2DSI was also useful for predicting the effect of resynchronizing therapy in congestive heart failure, and for assessing right ventricular (RV) function in rat models with pulmonary hypertension. SIDI derived from 2DSI might be one of promising index for assessing LV and RV function compared with conventional parameters.

Free Research Field

循環器内科学