Development of minimally invasive monitor of left atrial pressure, and its application to computer-controlled hemodynamic management system

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500565
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical systems
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: UEMURA Kazunori 独立行政法人国立循環器病研究センター, 研究所, 室長 (10344350)
• Co-Investigator(Renkei-kenkyūsha): KAWADA Toru 国立循環器病研究センター, 研究所, 室長 (30243752)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 心不全 / 左心房圧 / 肺動脈楔入圧 / 心臓エコー / 心筋組織ドプラー / 臨床応用 / 循環管理システム

Outline of Final Research Achievements

Assessing left atrial pressure (pulmonary capillary wedge pressure, PCWP) is essential in the care of patients with heart failure (HF). Physicians use right atrial pressure (RAP) to predict PCWP. However, the use of this method is limited. Our theoretical analysis indicated that PCWP can be predicted by RAP corrected by the relation between right and left ventricular function, provided by the ratio of tissue-Doppler systolic velocity of tricuspid annulus (ST) to that of mitral annulus (SM) (RAPｘST/SM). In animal experiments using 16 HF dogs, a stronger correlation was observed between RAPｘST/SM and PCWP than between RAP and PCWP (Heart Vessels 2014 in press). This was also confirmed in 98 HF patients (Circulation 130: A12904, 2014.). RAPｘST/SM enabled accurate prediction of PCWP in experimental and also in clinical settings. Furthermore, application of this technique to computer-controlled hemodynamic management system has realized stable and efficient control of HF hemodynamics.

Free Research Field

生体工学、循環生理学、心臓血管外科学