2014 Fiscal Year Final Research Report
A model that causes a decrease in the swallowing function in healthy people
| Project/Area Number |
24500630
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Kibi International University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOBASHI Motoi 岡山大学, 医歯(薬)学総合研究科 (80161967)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 嚥下障害 / 嚥下 / 満腹物質 / 摂食 / GLP-1 / 黒コショウ / カプサイシン / 香り |
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| Outline of Final Research Achievements |
It found that satiety by diet lowers the swallowing function. The advantage of this was to create a swallowing delay model which can perform in a healthy person. Swallowing suppression by the satiety rather than due to the rise of the blood sugar was revealed to be caused by stretching of the stomach. Stimulation of black pepper with improvement in swallowing function decline elderly patients were also effective in this model. In anaesthetized rats, it was investigated central mechanisms of swallowing suppression by satiety. Microinjection of glucagon like peptide-1(GLP-1) into the dorsal vagal complex (DVC) inhibited swallowing induced by central stimulation of the superior larygeal nerve. The inhibitory reponse was attenuated by treating exendin (5-39), a GLP-1 receptor antagonist, and by electrical lesion of medial NTS, but not commissural part of the NTS and the area postrema. These results suggest that GLP-1 inhibits reflex swallowing via medial NTS in the dorsal medulla.
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| Free Research Field |
生理学
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