Effect of rehabilitation on the plasticity of cortico-spinal tract after the spinal cord injury

2015 Fiscal Year Final Research Report

• Project/Area Number: 24500634
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: National Hospital Organization Murayama Medical Center
• Principal Investigator: Uemura Osamu 独立行政法人国立病院機構村山医療センター(臨床研究部), その他部局等, その他 (90365396)
• Co-Investigator(Kenkyū-buntansha): TAKEDA Kotaro 藤田保健衛生大学, 藤田記念七栗研究所, 准教授 (50618733)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 脊髄損傷 / 可塑性 / リハビリテーション

Outline of Final Research Achievements

To reveal the plastic changes of the cortico-spinal tract induced by rehabilitation after the spinal cord injury and to enhance the recovery with external stimulation, we attempted to generate transgenic rats that express channelrhodopsin-GFP fusion protein specifically in the cortico-spinal tract.
We have successfully obtained one transgenic-positive founder. We are currently examining the expression of the transgene.

Free Research Field

リハビリテーション医学