Receptor expressions of GH and IGF-1 in exercise-induced skeletal muscle adaptations

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500787
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Nagoya Institute of Technology
• Principal Investigator: HANAI Yoshiteru 名古屋工業大学, 工学(系)研究科(研究院), 准教授 (50360730)
• Co-Investigator(Renkei-kenkyūsha): YOSHIZATO Hideo 名古屋工業大学, 大学院工学研究科, 准教授
• Research Collaborator: 小畠 一輝 名古屋工業大学, 大学院工学研究科, 未来材料創成工学専攻 ; 林 敦也 名古屋工業大学, 大学院工学研究科, 未来材料創成工学専攻 ; 高木 裕士 名古屋工業大学, 生命物質工学科 ; 早田 陽紀 名古屋工業大学, 生命物質工学科 ; 鍋野 辰悟 名古屋工業大学, 生命物質工学科
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: GH / IGF-1 / GH受容体 / IGF-1受容体 / 筋肥大

Outline of Final Research Achievements

In the present study, we investigated the expression levels of GH receptor and IGF-1 receptor in rat skeletal muscles, to clarify the regulation mechanisms of these receptor expressions. The expression levels of these receptors differ between muscles, and expression pattern of these two receptors among muscles also not consistent. In the muscle hypertrophy models, at the onset of hypertrophic response (<4days), only GH receptor mRNA was down regulated. An independent regulatory mechanism of these two receptors was suggested.

Free Research Field

筋生理・生化学