2014 Fiscal Year Final Research Report
The roles of MAPkinase to the differentiation of regenerating fiber phenotype and the effects of heat stress
| Project/Area Number |
24500791
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Sports science
|
|---|
| Research Institution | Kumamoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | マップキナーゼ / ヒラメ筋 / 筋線維組成 / 速筋線維 / 遅筋線維 / ミオシン重鎖 / ラット / 再生筋線維 |
|---|
| Outline of Final Research Achievements |
The relation between the skeletal muscle fiber phenotype and mitogen-activated protein kinase (MAPK) was investigated. Adult rat soleus muscle which contains the highest of slow fibers expressed lowest MAPK protein, while the highest level of MAPK protein was observed at the superficial portion of the gastrocnemius muscle which contains the highest of fast type fibers. In addition, the percentage of slow type fibers increase in an anti-gravity rat soleus muscle with growing and maturation, at those period MAPK protein gradually decreased.
These results may suggest that MAPK protein is relating to the expression of fast phenotype of rat skeletal muscle fibers.
|
| Free Research Field |
運動生理学(骨格筋生理学・生化学)
|
