Effects of beta-oxidative lipid metabolism on onset and prevention of heat stroke by the heat exposure at exercise

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500800
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Tokyo University of Agriculture
• Principal Investigator: KASIMURA Osamu 東京農業大学, 国際食料情報学部, 教授 (40161020)
• Co-Investigator(Kenkyū-buntansha): HOSHI Akio 桐蔭横浜大学, スポーツ健康科学部, 教授 (20139265)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 熱中症 / β酸化系脂質代謝 / ヒドロアシルCoA脱水素酵素活性 / 熱ショックタンパク質72

Outline of Final Research Achievements

At first study, we made the heat stroke onset model rats, and this study examined tissue metabolism at onset of the heat stroke. Then, using those model rats, next study examined heat stroke prophylaxis. As the results, at the heat stroke onset, heat stress was burdened in order of the skeletal muscles, small intestine, cardiac muscle, kidney and liver, and that enzyme activities of the fat metabolisms beta-oxidation decreased more. Also, when it gave the α Reno lane acid-rich food before exercise under heat exposure, it was found that to inhibit the onset of the heat stroke, tissue heat stress and the decrease of the fat metabolism in the tissue.

Free Research Field

運動生理学