The factor of preferential inducing of fasting-related atrophy in fast-twitch muscle

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500804
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Hiroshima Shudo University
• Principal Investigator: OGATA Tomonori 広島修道大学, 人間環境学部, 准教授 (30434343)
• Co-Investigator(Renkei-kenkyūsha): OISHI Yasuharu 熊本大学, 教育学部 (10203704)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 筋萎縮 / 絶食 / 筋活動レベル

Outline of Final Research Achievements

The purpose of this study is to investigate why fasting-related muscle atrophy is preferentially induced in fast-twitch muscles compared with slow-twitch muscles. We focused on differences of muscular activity level between fast-and slow-twitch muscles, and used three types of experimental models 1) compensatory overloading; 2)sciatic nerve denervation; 3) cast immobilization. Increasing of mechanical loading reduced the rate of muscle atrophy in fast-twitch plantaris muscle. On the other hand, decreasing of muscle activity by denervation and cast immobilization increased the rate of muscle atrophy in slow-twitch soleus muscle. These findings indicate preferential inducing of fasting-related muscle atrophy in fast muscles is partially related with the frequencies of nerve activity and mechanical loading.

Free Research Field

運動生理学