2015 Fiscal Year Final Research Report
Preventive effects and molecular mechanisms for metabolic abnormalities by a short-term intervention of caloric restriction and exercise
| Project/Area Number |
24500849
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HIGUCHI Keiichi 信州大学, 学術研究院医学系, 教授 (20173156)
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| Research Collaborator |
LI Lin 信州大学, 医学系研究科, 大学院生
XU Zhe 信州大学, 医学系研究科, 大学院生
HUO Jia 信州大学, 医学系研究科, 大学院生
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 抗加齢 / 疾患モデルマウス / 軽度負荷運動 / 軽度カロリー制限 / 代謝改善 |
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| Outline of Final Research Achievements |
This study is a basic research that analyzed beneficial effects of metabolic improvement and a disease control in mice, which are middle-aged and older having metabolic abnormalities or which have a systemic disease with age, by short-term individual high-intensity running exercise (HR) and mild caloric restriction (CR). The combination of HR and CR might improve more efficiently in basal metabolism than each treatment, and both HR and CR improved in pathologic progress in mice having the age-associated disease. These treatments may prevent the progression of inflammation and stress reaction, and it suggests that HR and/or CR have good effects to age-related metabolic decline.
These treatments suggest the possibility of contribution to health promotion to middle-aged and elder people.
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| Free Research Field |
病態生化学、薬理学
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