2014 Fiscal Year Final Research Report
The intervention trail with excise to preserve cognitive function
| Project/Area Number |
24500851
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Nagoya University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
UMEGAKI Hiroyuki 名古屋大学, 医学部附属病院, 講師 (40345898)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | アルツハイマー病 / bio-markers / Aβ42 / p-tau / 運動 / MCI |
|---|
| Outline of Final Research Achievements |
In order to examine the effect of habitual exercise on cognitive functions and related bio-markers, older subjects diagnosed as mild cognitive impairment (MCI) were randomly assigned to two groups (intervention by exercise and no interventions) and changes of cognitive performances and those of bio-markers (Aβ42 and phosphorylated tau protein levels in the cerebrospinal fluid[CSF]) at six months from the baseline between the two groups were compared. During the study period 13 subjects participated and the results from 11 participants were obtained so far. The interim analysis revealed no significantly protective effects by habitual exercise on cognition during the period of observation (six months). However, a strong correlation was found between changes of Aβ42 and those of phosphorylated tau protein levels. Observed changes of bio-markers by habitual exercise, albeit from limited number of samples, suggested a possible effect of exercise program on CNS functions.
|
| Free Research Field |
アルツハイマー病
|
