2014 Fiscal Year Final Research Report
Importance of life-stile for the predicitive risk of metabolic syndrome
| Project/Area Number |
24500854
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 生活習慣病 / ライフスタイル / 喫煙 / 炎症 |
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| Outline of Final Research Achievements |
Smoking and metabolic syndrome are major public health problems in modern society and are important risk factors of cardiovascular disease. Smokers presented high IL-6 and CRP than never-smokers. For female smokers, visceral fat area was significantly high when compared to never-smokers. Smoking habit was considered as one of the important risk factors of visceral fat accumulation and progression of subclinical atherosclerosis in women. Serum levels of soluble α-klotho (αKl) were significantly higher in smokers than in never-smokers. SαKl was positively correlated with IL-6 and was associated with IL-6-related environmental stresses. Smoking affected the anti-inflammatory network and metabolic disorders. Acceleration of aging induced by smoking habit can be explained from two aspects, inflammation and metabolic disorders, associated with sαKl and FGF-21. The present data could provide new insights into the prevention of aging and aging-related diseases induced by smoking habit.
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| Free Research Field |
循環器内科学
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