A novel role for preventing the development of metabolic syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500859
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Oita University
• Principal Investigator: GOTOH KORO 大分大学, 医学部, 助教 (10457624)
• Co-Investigator(Kenkyū-buntansha): KAKUMA Tetsuya 大分大学, 医学部, 講師 (80343359) ; MASAKI Takayuki 大分大学, 医学部, 助教 (00423715) ; SEIKE Masataka 大分大学, 医学部, 助教 (40253794) ; CHIBA Seiichi 大分大学, 医学部, 助教 (20457633)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 脾臓 / IL-10 / メタボリックシンドローム

Outline of Final Research Achievements

High-fat diet (HFD) feeding induces the reduction of IL-10 synthesis from spleen and this decrease promotes inflammation and ectopic fat deposit in multiple organs, disorder of glucose and lipid metabolism, and hypertension. Moreover, switching to a low-fat diet (LFD) restores IL-10 synthesis in spleen and improved multiple organs damage induced by HFD feeding. Clinically, LFD feeding is recommended to prevent the development of metabolic syndrome. However, IL-10 synthesis ability derived from spleen is important to utilize switching from HFD to LFD1 feeding. Thus, "splenic function" might be necessary to consider the treatment strategy to metabolic syndrome.

Free Research Field

内分泌代謝