Elucidation of the molecular basis of FGF21, which holds the key to the metabolic control of nutrients, and preventive effect of lifestyle-related diseases.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500862
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: University of Shizuoka
• Principal Investigator: ARAI Hidekazu 静岡県立大学, 食品栄養科学部, 准教授 (60325256)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: FGF21 / 低GI成分 / 代謝動態

Outline of Final Research Achievements

FGF21 is an important factor regulating glucose and lipid metabolism, details of the expression regulatory mechanism is not known. Therefore, in the present study was aimed to elucidate the expression mechanism of FGF21 by different dietary intake of monosaccharides and PFC ratio. In vivo and in vitro, fructose administration increased the FGF21 mRNA expression, and induced FGF21 in the early time as compared to glucose administration. Furthermore, to give a different diet PFC ratio in rats, FGF21 gene expression was increased when carbohydrate intake is reduced. Thus, it was suggested that the quality and quantity of the carbohydrate might induce expression of FGF21 gene.

Free Research Field

臨床栄養学