The influence of macrophage differentiation on decreasing physical activity in metabolic syndrome

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500878
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kawasaki University of Medical Welfare
• Principal Investigator: YANO HIROMI 川崎医療福祉大学, 医療技術学部, 准教授 (20248272)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Taxiscan / M1マクロファージ / M2マクロファージ / 筋損傷モデル / C2C12細胞 / J774細胞 / MCP-1 / CCR2

Outline of Final Research Achievements

In order to clarify that our hypothesis is that the decreasing physical activity in metabolic syndrome might be induced by macrophage differentiation, we investigated the effect of macrophage differentiation on the chemotactic activity to invade local damaged muscle using in vitro models of muscle injury. Although the chemotactic activity of M1 macrophages disappeared completely, M2 cells exhibited accelerated chemotactic activity toward damaged muscle cells. These results suggest that the metabolic syndrome-induced reduction of physical activity depend on the differentiation of M1 type of macrophages, which show a decrease in chemotaxis towards damaged myocytes.

Free Research Field

運動免疫学