WHY DOES THE DECREASED RESISTANCE FOR STRESS WITH DIABETES HAPPEN?

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500880
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Nakamura Gakuen College
• Principal Investigator: AOMINE MASAHIRO 中村学園大学, 栄養科学部, 名誉教授 (60091261)
• Co-Investigator(Kenkyū-buntansha): YAMATO Takako 中村学園大学, 栄養科学部, 准教授 (70271434) ; NISHIMORI Atsuko 中村学園大学, 栄養科学部, 助手 (90461475) ; NIGO Ryosuke 中村学園大学短期大学部, 食物栄養学科, 助教 (20565767) ; MATSUOKA Tomomi 中村学園大学, 栄養科学部, 助手 (80637033)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 糖尿病 / ストレス抵抗性 / 副腎除去 / ラット

Outline of Final Research Achievements

It is reported that the activity of hypothalamic-pituitary-adrenal axis is involved in stress response and diabetic patients have fragile response for stress. In this study, the behavioral activity and neurotransmitter serotonin release from brain after stress-loading were compared with the findings without stress-loading, using diabetic rat and diabetic adrenalectomized rat. Diabetes led to decrease the locomotor activity, and adrenalectomy further caused decrease of the activity. However, there was no significant difference between before and after stress-loading. No significant changes of serotonin release also occured after adrenalectomy. Unfortunately as adrenalectomized operation produced very high mortality, especially in the diabetic rat, obtained experimental results were not sufficient. However, these findings, at least in part, suggest that adrenalectomy is not significantly responsible for the fragile response for stressors in diabetic patients.

Free Research Field

栄養生理学