Mechanism of anti-inflammatory property of dietary fiber through glucan receptor on small intestinal epitherial cells

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500974
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kobe University
• Principal Investigator: MIZUNO Masashi 神戸大学, (連合)農学研究科(研究院), 教授 (00212233)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: Lentinan / Dectin-1

Outline of Final Research Achievements

In this study, the mechanism of anti-inflammation by lentinan was investigated. Lentinan was orally administered to Dectin-1 knockout (Dectin-1 KO) mice which were treated by DSS to induce colitis. Oral administration of lentinan (100 μg/mouse/day) did not show any significant improvement in DSS-induced Dectin-1 KO mice. Moreover, TNFR1 mRNA expression in intestinal epithelial cells was decreased by lentinan administration to wild type mice, but not Dectin-1 KO mice. These results revealed that lentinan may exert its anti-inflammatory activities through the beta-glucan receptor Dectin-1 with the decrease of TNFR1 in intestinal epithelial cells.

Free Research Field

食品化学