Vitamin and chronic obstructive airway disease

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Tottori University
• Principal Investigator: YAMASAKI Akira 鳥取大学, 医学部附属病院, 講師 (70325009)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: ビタミン / トコトリエノール / 気道平滑筋細胞 / 閉塞性肺疾患

Outline of Final Research Achievements

The relationships among oxidative stress marker, serum vitamin levels and phisical activity index in patients with chronic airway disease were studied. The serum vitamin levels were not related to physical activity index or oxidative stress levels. Therefore, the vitamin levels might not be related to oxidative stress at short time study. The long term and prospective study is needed to investigate the effects of vitamin on patients with airway diseases.
We also studied the effect of tocotrienol on human airway smooth muscle cells. Alfa, gamma and delta tocotrienol reduced airway smooth muscle cell proliferation and migration induced by PDGF-BB. This inhibitory effect is mediated by inhibtion of RhoA activation. We also found that gamma tocotrienol inhibited collagen I and fibronectin expression increased by TGF-beta1. These results indicate that tocotrienol could have benifical effects for airway remodeling in asthma by inhibiting several functions of airaway smooth muscle cells.

Free Research Field

呼吸器内科