2014 Fiscal Year Final Research Report
Effects of lipids on the function of thymic epithelial cells
| Project/Area Number |
24500979
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OWADA Yuji 山口大学, 大学院・医学系研究科, 教授 (20292211)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 胸腺上皮細胞 / 脂肪酸結合タンパク / FABP / 脂肪酸 |
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| Outline of Final Research Achievements |
In the present study, we examined the effect of fatty acids and function of fatty acid-binding protein 5 (FABP5) in thymopoiesis, morphology and proliferation/differentiation of thymic epithelial cells through the comparison of wild-type (WT) and FABP5-knock out (KO) mice. We found that long chain-polyunsaturated fatty acids (LC-PUFAs) and rerinoic acid (RA) promotes proliferation of cultured thymic epithelial cells via FABP5 rather than the specific function of thymic epithelial cells which regulates differentiation of thymocytes.
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| Free Research Field |
分子細胞生物学、解剖学
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