Suppressive effects of rice proteins on progression of kidney disease in type 2 diabetic model rats

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500983
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: University of Niigata Prefecture
• Principal Investigator: WATANABE Reiko 新潟県立大学, その他, 名誉教授 (70141348)
• Co-Investigator(Renkei-kenkyūsha): KADOWAKI Motoni 新潟大学, 自然科学系, 教授 (90126029)
• Research Collaborator: KUBOTA Masatoshi 新潟大学, 超域学術院, 助教 (00595879)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 米胚乳タンパク質 / 米糠タンパク質 / ２型糖尿病 / 糖尿病性腎症 / 非肥満糖尿病モデルGKラット / 肥満糖尿病モデルZDFラット

Outline of Final Research Achievements

Ameliorative effect of rice endosperm protein (REP) on diabetic nephropathy was suggested to be caused by the suppression of renal MCP-1 rise in non-obese, spontaneous type 2 diabetic Goto-Kakizaki rats. In Zucker Diabetic Fatty rats, which are an animal model of obese type 2 diabetes mellitus, dietary REP and rice bran protein (RBP) delayed in the progression of renal failure. In addition, REP and RBP markedly suppressed lipid accumulation in the liver and improved glucose homeostasis parameter such as hemoglobin A1c. The analysis of gene expression data of the liver and kidney obtained using microarray experiments showed both the effect of rice proteins on contributing to the increased expression of glycolytic enzyme-related genes in the liver and, in the kidney, the decrease of inflammatory gene expression, and the increase of oxidative stress-related gene expression.

Free Research Field

食生活学・食と栄養