Study on function of the cocked rice of the Japanese staple food

2014 Fiscal Year Final Research Report

• Project/Area Number: 24500993
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Josai University
• Principal Investigator: SHIMIZU Jun 城西大学, 薬学部, 講師 (70297597)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 炊飯米 / デキストラン硫酸ナトリウム / 潰瘍性大腸炎 / DNAマイクロアレイ / 米ペプチド

Outline of Final Research Achievements

In this study, we investigated to clarify whether cocked rice (CR) improved the DSS-induced colitis of the mouse. We found that the oral CR improved a symptom of the colitis with the weight loss and MPO activity of the mouse. In addition, gene expression analysis of colon tissue by DNA microarrays, CR increased the expression of cell cycle-related genes. Furthermore, rice-derived peptides were considered to maintain the barrier function of the intestinal tissue that was induced inflammation. These results suggest that dietary CR may relieve the prevention and improvement of inflammatory bowel disease.

Free Research Field

食品機能学