Does the insulin-inducible transcription factor SHARP gene family involve in down-regulation of the blood glucose level?

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501002
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Matsumoto University
• Principal Investigator: YAMADA KAZUYA 松本大学, 健康科学研究科, 教授 (20263238)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: SHARP 遺伝子 / インスリン / 糖尿病 / 血糖低下 / シグナル伝達 / 食品成分

Outline of Final Research Achievements

SHARP-2, an insulin-inducible transcriptional repressor, involves in the down-regulation of the blood glucose level by repressing the transcription of the gluconeogenic enzyme gene.
In this study, we showed that SHARP-1, another SHARP family gene, also contributed the down-regulation of the blood glucose level by insulin. We then showed signal transduction pathways mediating the induction of expression of both the SHARP-1 and the SHARP-2 genes by insulin or the SHARP-2 gene by AICAR. Furthermore, we identified both an isoflavone-metabolite (S)-Equol and a green tea catechin as food constituents mimicking the insulin action and analyzed the signal transduction pathways.

Free Research Field

Molecular biology