Putative effects of energy restriction and exercise on abnormal feeding behavior and ghrelin production in obese diabetic model

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501018
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Kurume University
• Principal Investigator: TAJIRI YUJI 久留米大学, 医学部, 准教授 (80469361)
• Co-Investigator(Kenkyū-buntansha): MIFUNE Hiroharu 久留米大学, 医学部, 准教授 (70174117) ; NISHI Yoshihiro 久留米大学, 医学部, 講師 (20352122) ; YAMADA Kentaro 久留米大学, 医学部, 教授 (10191305)
• Co-Investigator(Renkei-kenkyūsha): KOJIMA Masayasu 久留米大学, 分子生命科学研究所, 教授 (20202062)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 肥満 / 摂食ホルモン

Outline of Final Research Achievements

Abnormal eating behavior is often observed in patients with obesity and type 2 diabetes, making controls of body weight and metabolic parameters more difficult. In the present study, we investigated a putative relationship between overeating and ghrelin, an appetite promoting hormone in SDT-fatty rats (fa) as a model of obese type 2 diabetes. At 16 weeks old, fa showed massive overeating, especially during light phase, with a concomitant but slight increase of stomach ghrelin production. Although a clear diurnal rhythm of plasma ghrelin concentration was observed with peaks at 7:00 and 19:00 in control SD rats, such rhythm was obscure and peaks had shifted in fa. This abnormal rhythm of ghrelin, not an abnormal production, might well explain feeding behavior during light phase in this obese model. Furthermore, we evaluated effects of voluntary exercise on rhythms of feeding and locomotor activity in relation to an amelioration of ghrelin production in high fat diet-induced obese rats.

Free Research Field

内分泌代謝・糖尿病