2014 Fiscal Year Final Research Report
Studies on the active ingredients in functional foods for risk reduction of the metabolic syndrome
| Project/Area Number |
24501021
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Shokei University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 機能性食品成分 / メタボリック症候群 / ポリフェノール / フラボノイド |
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| Outline of Final Research Achievements |
To demonstrate the role of polyphenols in reducing cardiovascular disease risk through an improvement in vascular function, we examined the direct effects of polyphenols on the proliferation of smooth muscle cells and the contractile response of aortas from a mouse model of the metabolic syndrome. High glucose-induced proliferation of the primary cultured aortic smooth muscle cells of mice was significantly inhibited by genistein and daidzein. In aortas from high fat diet (HFD)-induced obese mice, cyanidin or naringenin evoked relaxation via not only endothelial nitric oxide (NO) but also potassium channel activation. Further, naringenin enhanced acetylcholine-induced relaxation even after inhibition of NO synthase. These results suggest that the polyphenols might be effective in regulating vascular tone in HFD mice through endothelial nitric oxide synthase activation and direct actions on the smooth muscle cells.
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| Free Research Field |
生活科学
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