The development of chrononutrition-based dietary instructions for the prevention and treatment of lifestyle-related diseases

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501028
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Department of Clinical Research, National Hospital Organization Kyoto Medical Center
• Principal Investigator: TSUZAKI Kokoro 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (80450881)
• Co-Investigator(Kenkyū-buntansha): SAKANE Naoki 独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究室長(予防医学) (40335443) ; KOTANI Kazuhiko 自治医科大学, 医学部, 准教授 (60335510)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 時間栄養学 / 脂質代謝 / 生活習慣病 / 食事指導 / 予防医学

Outline of Final Research Achievements

We investigated the relationships among eating schedule, lipoprotein metabolisms (small dense LDL; sdLDL), and the CLOCK 3111T/C polymorphism in women with dyslipidemia. In carriers of T/T homozygotes, the area of sdLDL was slightly higher than that in carriers of the C alleles (T/C or C/C). As carriers of T/T homozygotes had breakfast earlier, their morning fasting time was shorter than carriers of the C alleles.
Interventions were performed simultaneously in rotating shift and day shift groups to assess whether the group-based lifestyle intervention affects body weight in male shift workers. There was no difference in body weight between the 2 groups before the intervention; however, weight loss was significantly smaller in the rotating shift group than that in day shift groups after the intervention.

Free Research Field

時間栄養学、予防医学、脂質学