2014 Fiscal Year Final Research Report
Identification of the role of Vasohibin-2 in tumor malignancy and its application in novel cancer therapy
| Project/Area Number |
24501309
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | Vasohibin / 上皮間葉転換 / 癌悪性化 / 炎症 / 血管新生 / miR-200 / 胃癌 / 脂質結合 |
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| Outline of Final Research Achievements |
In this study, the role of Vashibin-2 (VASH2) in tumor malignancy was analyzed. The expression level of VASH2 in cancer cells was regulated by miR-200 family, and affected cancer cell migration and invasion mediated by epithelial-mesenchymal transition-related (EMT) gene expressions. Purified VASH2 protein selectively interacted with some types of phospholipids (e.g. cardiolipin and phosphatidic acid), and its interaction affected the extracellular secretion of VASH2 protein from cancer cells. The expression of Vash2 mRNA was significantly increased in mouse gastric tumors compared with normal mucosa. Knocking out of Vash2 gene suppressed gastric tumor growth accompanying the down-regulation of gene expressions related to cancer growth, inflammation, and angiogenesis (e.g. Epiregulin and Interleukin-11). These results suggest that VASH2 may influence tumor malignancy via EMT and inflammation beside its role in angiogenesis.
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| Free Research Field |
基礎医学
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