2014 Fiscal Year Final Research Report
Analysis of cell death regulation by Prohibitin and Hint2 under hypoxia
| Project/Area Number |
24501312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Keio University (2013-2014)
The University of Tokyo (2012) |
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Principal Investigator |
SATOH Kiyotoshi 慶應義塾大学, 政策・メディア研究科, 助教 (50401386)
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| Co-Investigator(Kenkyū-buntansha) |
KUBOTA Shunichiro 帝京平成大学, 薬学部, 教授 (00260480)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 細胞死 / 低酸素 / 癌 |
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| Outline of Final Research Achievements |
Cancer cells are more resistant to hypoxia than normal cells. We found that mitochondrial protein Prohibitin was decreased under hypoxic conditions, and that overexpression of Prohibitin inhibited cell death induced by hypoxia. Furthermore, Knockdown of Prohibitin in human colon cancer cells reduced S phase cell fraction and decreased cell proliferation. In addition, we analyzed functional cooperation of Prohibitin and mitochondrial protein Hint2 in colon cancer cells.
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| Free Research Field |
腫瘍生物学
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