2014 Fiscal Year Final Research Report
Generation of cancer stem cell library from iPS cells for development of drug screening system
| Project/Area Number |
24501315
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SENO Masaharu 岡山大学, 大学院自然科学研究科, 教授 (90243493)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | がん幹細胞 / 薬剤スクリーニング / iPS / ドラッグデリバリー / がん幹細胞ニッチ / エクソソーム |
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| Outline of Final Research Achievements |
In the study of cancer and development of new anticancer drug, cancer stem cells (CSCs) are now considered to be important targets. In this study, we developed a drug screening system using various mouse iPS-derived cancer stem model cells (miPS-CSCs). In addition, we analyzed the gene expression profiles of miPS-CSCs, which focus on cell surface protein to use targeted drug delivery system. Comparison with normal tissue distribution, we nominated several candidate genes for tissue specific targeting.
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| Free Research Field |
分子生物学
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