Progression of the sporadic medulloblastoma and its interaction with the microenvironment in a mouse model sysytem.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501324
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: YAGINUMA Katsuyuki 公益財団法人がん研究会, がん研究所 細胞生物部, 研究員 (40182307)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: がん抑制遺伝子 / Patched1 / Medulloblastoma / 腫瘍微小環境 / CXCR3 receptor signaling / 腫瘍モデルマウス

Outline of Final Research Achievements

A mouse model for sporadic medulloblastoma has been successfully established. Progression of medulloblastoma in the cerebellum tissue was observed to be affected by the genetic background of a model mouse, implicating that the gene dosage of the tumor suppressor gene , Patched1 (Ptc1), has a critical role not only for tumor formation, but for tumor microenvironment. In the cerebellum of Ptc1(+/-) mice, expression of CXCL9 for immune response is elevated significantly, and CXCL10 is also highly expressed in the tumor tissue itself. These chemokines are specific ligands for activation of the CXCR3 receptor signaling pathway, and it was suggested that this pathway is critically involved in forming a microenvironment for tumor progression through the regulation of the microglia-mediated immune response .

Free Research Field

実験腫瘍学