Roles for pyruvate kinase M in tumorigenesis

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501326
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor biology
• Research Institution: Miyagi Prefectural Hospital Organization Miyagi Cancer Center
• Principal Investigator: TANUMA NOBUHIRO 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
• Co-Investigator(Kenkyū-buntansha): YAMASHITA Yoji 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (30420045) ; ITO Shigemi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: PKM / 代謝 / ワールブルグ効果 / スプライシング / がん

Outline of Final Research Achievements

Two isoforms of pyruvate kinase M (Pkm), Pkm1 and Pkm2, differentially control flux of carbon sources from glycolysis to TCA cycle. Thus the abundance of Pkm1 and Pkm2 within cells is important to tune a balance between glycolysis and aerobic metabolism. Using primary cells of the mice which are genetically engineered to express only a single isoform of each Pkm, it was revealed that both Pkm1- and Pkm2-driven metabolism play unique and essential roles in cell-fate decisions during cellular senescence and immortalization/trans-formation processes.

Free Research Field

腫瘍生物学