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2014 Fiscal Year Final Research Report

Roles for pyruvate kinase M in tumorigenesis

Research Project

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Project/Area Number 24501326
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Tumor biology
Research InstitutionMiyagi Prefectural Hospital Organization Miyagi Cancer Center

Principal Investigator

TANUMA NOBUHIRO  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)

Co-Investigator(Kenkyū-buntansha) YAMASHITA Yoji  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (30420045)
ITO Shigemi  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
Project Period (FY) 2012-04-01 – 2015-03-31
KeywordsPKM / 代謝 / ワールブルグ効果 / スプライシング / がん
Outline of Final Research Achievements

Two isoforms of pyruvate kinase M (Pkm), Pkm1 and Pkm2, differentially control flux of carbon sources from glycolysis to TCA cycle. Thus the abundance of Pkm1 and Pkm2 within cells is important to tune a balance between glycolysis and aerobic metabolism. Using primary cells of the mice which are genetically engineered to express only a single isoform of each Pkm, it was revealed that both Pkm1- and Pkm2-driven metabolism play unique and essential roles in cell-fate decisions during cellular senescence and immortalization/trans-formation processes.

Free Research Field

腫瘍生物学

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Published: 2016-06-03  

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