2014 Fiscal Year Final Research Report
Effective anti-cancer immunotherapy by controling autophagy
| Project/Area Number |
24501331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor immunology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | 癌免疫療法 / アポトーシス / TRAIL / オートファジー |
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| Outline of Final Research Achievements |
Autophagy is a cell survival system under starvation or stress. Cancer cells utilize this system to acquire therapy-resistance and adjust hypoxic tumor microenvironment. I found that autophagy is induced when human pancreatic cancer cells are treated with apoptosis-inducing TRAIL. Additionally, their susceptibility to TRAIL is significantly augmented by the treatment with RNA interference or molecular-targeted drugs to inhibit autophagy.
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| Free Research Field |
腫瘍免疫
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