Peripheral location, TTF-1 expression and prognosis of SCLC

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501347
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor diagnosis
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: NISHIO Makoto 公益財団法人がん研究会, その他部局等, その他 (00281593)
• Co-Investigator(Kenkyū-buntansha): ISHIKAWA Yuichi 公益財団法人がん研究会がん研究所, 病理部, 部長 (80222975)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 小細胞肺がん / TTF-1

Outline of Final Research Achievements

In this study, we examined whether SCLC is really a central-type tumor and the relationship between tumor location, TTF-1 expression and prognosis of SCLC.　Ninety six SCLCs, diagnosed from biopsies or surgical materials, for which detailed computed tomography (CT) images were available, were collected consecutively from Japanese patients between 2004 and 2011. We examined the location of the primary tumor (central or peripheral) using thin-sliced CT, a TTF-1 immunohistochemical expression, and clinicopathology including prognosis.Of the 96 SCLCs, 75% were of the peripheral type and found to have a significantly worse prognosis than central-type tumors. TTF-1 expression was significantly correlated with peripheral location (p = 0.030). Multivariate analysis revealed that high TNM stages and the peripheral location were independent markers for poor survival. TTF-1 is a marker for peripheral location and a poor prognosis for SCLC.

Free Research Field

臨床腫瘍学