The role of glucocorticoid in mitochondria-dependent resistance to anticancer therapy

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501353
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: Osaka City University
• Principal Investigator: KASAHARA EMIKO 大阪市立大学, 医学(系)研究科(研究院), 講師 (30468269)
• Co-Investigator(Kenkyū-buntansha): KUBO Shuji 兵庫医科大学, 医学部, 准教授 (10441320)
• Co-Investigator(Renkei-kenkyūsha): SEKIYAMA Atsuo 大阪大学, 薬学研究科, 教授 (30403702)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: グルココルチコイド / ミトコンドリア / 抗がん剤 / ストレス / 中皮腫

Outline of Final Research Achievements

Those intense stress by a side effect of chemotherapy as well as the pain with the cancer also influence the therapeutic effects of the anticancer agents.
However, little is known about the mechanisms of these untoward actions. In this study, we investigated the influence of glucocorticoids, which is a stress-related hormone on anticancer drug actions. Our results suggest that stress-induced glucocorticoids attenuate the action of anticancer drug through the alteration of mitochondrial function.

Free Research Field

生化学