Development of a novel small-molecule compounds targeting cancer stem cells derived from malignant glioma

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501362
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Clinical oncology
• Research Institution: Shizuoka Cancer Center Research Institute
• Principal Investigator: ASHIZAWA Tadashi 静岡県立静岡がんセンター(研究所), その他部局等, その他 (10443441)
• Co-Investigator(Kenkyū-buntansha): AKIYAMA Yasuto 静岡県立静岡がんセンター研究所 (70222552) ; ANDO Takayuki 静岡県環境衛生科学研究所 (40402226)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: がん幹細胞治療薬

Outline of Final Research Achievements

Despite of an intensive therapy, the prognosis of malignant gliomas is still poor, and average overall survival is only about a year. Therefore, the development of new drugs against gliomas has been required. In recent years, the novel therapeutic regimens against cancer stem cells have been investigated. In the current study, We established a small-molecule compound library screening system consisting of in silico study and in vitro proliferation assay using glioma patients-derived stem cell lines in a collaboration with Shizuoka Institute of Environment and Hygiene. So far we found that five promising compounds which have potent inhibitory activity on stem cell proliferation, and even a few compounds showed anti-stem cell tumor activity in vivo. In the future, through preclinical safety and drug delivery study of identified compounds, we are planning to pursue the possibility of a new therapeutic agent against glioma stem cell.

Free Research Field

分子標的治療