Nutrition and molecular genetic epidemiology analysis of prostate cancer

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cancer epidemiology and prevention
• Research Institution: Kumamoto University
• Principal Investigator: KATOH Takahiko 熊本大学, 大学院生命科学研究部, 教授 (70169506)
• Co-Investigator(Renkei-kenkyūsha): YAMANO Yuko 昭和大学, 医学部, 准教授 (30167580) ; TAKAHASHI Hiroyuki 慈恵会医科大学, 医学部, 准教授 (00246414)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 前立腺がん / 分子疫学 / 栄養学 / 予防医学

Outline of Final Research Achievements

We conducted a comprehensive epidemiological analysis of genetic and environmental factors to clarify the risk factors for prostate cancer (PCa) in Japanese nationals.
Result: 1) There are no significant increased risks of PCa on quantified nutrients at present. 2) Estrogen receptor 2 (ESR2) rs4986938 AG and AG + AA genotypes were associated with significantly decreased risk of PCa (AG: OR= 0.68, 95% CI, 0.47-0.97, P < 0.05 and AG + AA: OR= 0.67, 95% CI, 0.47-0.94, P< 0.05). When patients were grouped according to smoking status, the ESR2 rs1256049 AA genotype (OR= 0.48, 95% CI, 0.25-0.95, P< 0.05) and ESR2 rs4986938 AG + AA genotype (OR= 0.64, 95% CI, 0.41-1.00, P< 0.05) showed significantly decreased PCa risk in the ever-smoker group.

Free Research Field

疫学