Exposure assessment of heterocyclic aromatic amines among Japanese and Japanese Brazilians.

2014 Fiscal Year Final Research Report

• Project/Area Number: 24501366
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cancer epidemiology and prevention
• Research Institution: National Cancer Center Japan
• Principal Investigator: IWASAKI Motoki 独立行政法人国立がん研究センター, がん予防・検診研究センター, 部長 (60392338)
• Co-Investigator(Renkei-kenkyūsha): TSUGANE Shoichiro 独立行政法人国立がん研究センター, がん予防・検診研究センター, センター長 (40179982)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 曝露評価 / 生体試料 / 食物摂取頻度調査票 / 妥当性研究 / 日系人

Outline of Final Research Achievements

We conducted validation studies using PhIP level in hair to establish the method of exposure assessment for heterocyclic aromatic amines (HAAs) among Japanese and Japanese Brazilians. The validation study in Japanese suggested that our food frequency questionnaire (FFQ) for Japanese is reasonably valid for the assessment of HAA intake. On the other hand, the validation study in Japanese Brazilians suggested that the assessment of HAA intake by FFQ for Japanese Brazilians should be revised. When PhIP level in hair was used as exposure indicator, it was higher in Japanese Brazilians than Japanese.

Free Research Field

がん疫学