2015 Fiscal Year Final Research Report
Identification of the repair enzymes for oxidatively damaged bases-Analysis of the mechanism for protection of ionizing radiation and reactive oxygen species
| Project/Area Number |
24510071
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 酸化的損傷塩基 / DNA修復 / 活性酸素 / 電離放射線 / 突然変異 / 線虫 |
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| Outline of Final Research Achievements |
Reactive oxygen species (ROS) are generated continually in living cells during normal cellular metabolism and also generated by exogenous sources such as ionizing radiation and various chemical oxidants. ROS are highly reactive and damage DNA, causing strand breaks and many types of damaged bases. If such damages are not eliminated or repaired, they lead to cellular dysfunction, cell death, mutations, cancer and aging. Cells protect themselves from ROS by preventing oxidative cellular damage, through repair of oxidative damages. In this study, we identified several DNA repair enzymes from C. elegans, and clarified their involvement in aging, embryo development and body growth. We also analysed the role of DNA repair enzymes against biological consequences of ionising radiation.
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| Free Research Field |
放射線生物学
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