Comparative toxicology of triazine herbicides focusing on delayed metamorphosis and malformations during the postembryonic development of anurans

2014 Fiscal Year Final Research Report

• Project/Area Number: 24510088
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation/Chemicals
• Research Institution: Kyoto Prefectural Institute of Public Health and Environment
• Principal Investigator: SAKA Masahiro 京都府保健環境研究所, 水質課, 主任研究員 (80419192)
• Co-Investigator(Renkei-kenkyūsha): TADA Noriko 京都府保健環境研究所, 水質課, 主任研究員 (70419191)
• Research Collaborator: KAMATA Yoichi 岩手大学, 農学部, 教授 (20152837)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: カエル / 後期発生 / トリアジン / 除草剤 / 成長阻害 / 発生遅延 / 奇形 / 甲状腺

Outline of Final Research Achievements

Triazines have been commonly used as herbicides on a global scale. Although toxic effects of triazines have been intensively studied, chronic toxicity of triazines on amphibians is still controversial. We revealed non-lethal toxic effects of seven triazine herbicides on the anuran postembryonic development by conducting long-term exposure tests using premetamorphic tadpoles of Western clawed frogs. Our morphometric results consistently indicated that the triazines acted as a chemical stressor inhibiting tadpole growth and/or development in a thyroid-inactive mode. In addition, it was demonstrated that the triazines had teratogenicity to induce axial malformations in developing tadpoles.

Free Research Field

環境毒性学