2015 Fiscal Year Final Research Report
Biological significance of the duplicated GGAA-motifs in the human TATA-less gene promoters
| Project/Area Number |
24510270
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Genome biology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
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| Research Collaborator |
TANUMA Sei-ichi 東京理科大学, 薬学部・薬学科, 教授
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 転写制御 / GGAA / ISG / OAS1 / ELF-1 / TP53 / HELB / ETS |
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| Outline of Final Research Achievements |
In this study, it was revealed that anti-viral factor encoding OAS1 gene is up-regulated by ELF-1, suggesting a new therapeutic method for leukemia introducing the transcription factor encoding gene(s) into cells. Moreover, it was shown that a natural compound resveratrol affects duplicated GGAA-motifs to activate promoter activities of the human TP53 and HELB genes, which encode tumor suppressor p53 and G1/S transition regulatory DNA helicase, respectively. The results suggest that natural product or introduction of specific genes into cells could be applied for cancer treatment up-regulating DNA-repair system at a transcriptional level. On the basis of these observations, we have started to investigate promoter regions of the human mitochondrial-function or DNA-repair associated genes analyzing their responses to various anti-tumor/anti-aging drugs.
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| Free Research Field |
分子生物学
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