2014 Fiscal Year Final Research Report
Assessing the clinical utility of the genetic information using the genotype data for GWAS-derived type 2 diabetes susceptibility variants in a Japanese population.
Project/Area Number |
24510276
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical genome science
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Research Institution | University of Toyama |
Principal Investigator |
IWATA MINORU 富山大学, 大学院医学薬学研究部(医学), 准教授 (20345565)
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Co-Investigator(Kenkyū-buntansha) |
TOBE Kazuyuki 富山大学, 大学院医学薬学研究部(医学), 教授 (30251242)
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Research Collaborator |
HARA Kazuo 東京大学, 医学部附属病院糖尿病・代謝内科 (50359600)
MAEDA Shiro 琉球大学大学院医学研究科, 先進ゲノム検査査医学講座・独立行政法人理化学研究所遺伝子多型研究センター (50314159)
KAMURA Yutaka
NAKAGAWA Hajime
TAKANO Atsuko
KATO Hiromi
TEMARU Rie
FUKUSHIMA Yasuo
HIGUCHI Kiyohiro
TAKI Kazuko
IGARASHI Yasuhumi
SAWASAKI Shigeki
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Keywords | 疾患関連遺伝子 / ゲノム |
Outline of Final Research Achievements |
We evaluated the clinical usefulness of a genetic risk score (GRS) based on 14 well-established variants for type 2 diabetes(T2D). We analyzed 14 SNPs at HHEX, CDKAL1, CDKN2B, SLC30A8, KCNJ11, IGF2BP2, PPARG, TCF7L2, FTO, KCNQ1, IRS-1, GCKR, UBE2E2, and C2CD4A/B in 1487 Japanese individuals (724 patients with T2D and 763 controls). A GRS was calculated according to the number of risk alleles by counting all 14 SNPs (T-GRS) as well as 11 SNPs related to β-cell function (β-GRS) and then assessing the association between each GRS and the clinical features. The T-GRS was significantly associated with T2D (P = 5.9 × 10-21). Among the subjects with T2D, the β-GRS was associated with individuals receiving insulin therapy ( P = 0.0431), age at diagnosis (P = 0.0029), and C-peptide index (P = 0.0125). Our data suggests that the β-GRS is associated with reduced beta cell functions and may be useful for selecting patients who should receive more aggressive β-cell preserving therapy.
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Free Research Field |
代謝・内分泌学
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