Structural transformation of a diarrhetic shellfish toxin, okadaic acid, in scallops

2014 Fiscal Year Final Research Report

• Project/Area Number: 24510291
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Living organism molecular science
• Research Institution: Tohoku University
• Principal Investigator: KONOKI Keiichi 東北大学, (連合)農学研究科(研究院), 准教授 (40292825)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: 下痢性貝毒 / 解毒機構 / オカダ酸 / 変換酵素

Outline of Final Research Achievements

Shellfish poisoning is one of food poisoning that has causes financial breakdown the aquaculture industry. When the concentration of toxic substance synthesized by a specific type of plankton is beyond the regulated level, shipping of bivalves is stopped. Thus, it is important to elucidate a mechanism of the detoxification in bivalves. In this study, we studied a structural transformation of okadaic acid, a diarrhetic shellfish toxin, because the transformation was considered to be a key reaction for the detoxification. The results of our research study are 1) the structural modification proceeds only in the digestive gland of bivalve species; 2) the enzyme might be a membrane protein identified in the microsomal fraction; 3) the structural modification proceeds in various bivalve species.

Free Research Field

天然物化学