2015 Fiscal Year Final Research Report
Search for new fluorescent natural products from medicinal plants and their properties in living cells
| Project/Area Number |
24510293
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Nihon University (2013-2015)
Tokyo Medical and Dental University (2012) |
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Principal Investigator |
OHSAKI Ayumi 日本大学, 文理学部, 准教授 (50161360)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUYAMA Yoshiyasu 徳島文理大学, 薬学部, 教授 (70208990)
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | 天然蛍光物質 |
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| Outline of Final Research Achievements |
In this study, we performed screening studies of fluorescent compounds derived from tropical medicinal plants. A strongly fluorescent compound, amarastelline A, consisting of a canthin unit and a carboline unit, was isolated from Quassia amara. Its fluorescent properties in various solvents and its ability to stain the cell cytoplasm of living HeLa cells were investigated. Furthermore, the total synthesis of amarastelline A and its derivatives were studied.
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| Free Research Field |
天然物化学
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