2015 Fiscal Year Final Research Report
Development of novel synthetic method of carbohydrate probes toward medicinal applications
| Project/Area Number |
24510297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Wakayama University |
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Principal Investigator |
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | シアロ糖鎖 / 糖鎖プローブ / 免疫 / 自動合成 / 酵素合成 |
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| Outline of Final Research Achievements |
Carbohydrates play important roles in numerous physiological processes. For example, cell migration, recognition, morphogenesis, cancer cell metastasis and so on. Sialo-sugar chain is a generic term for sugar chains having a sialic acid at the non-reducing end. It has been elucidated that many sialo-sugar chains are present in cancer related carbohydrate antigens. In the present study, we succeeded the synthetic mythology of sialo-sugar chains and its probes utilizing trans glycosylation activity of neuraminidase. The system that is able to synthesize the sialo-sugar chains automatically like the peptide synthesis, though it is limited in present stage.
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| Free Research Field |
糖鎖生命科学
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