2014 Fiscal Year Final Research Report
Mechanism of starfish's autotomy and a pain were related
| Project/Area Number |
24510303
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Tohoku Pharmaceutical University |
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Principal Investigator |
UKAI Kazuyo 東北薬科大学, 薬学部, 助教 (60433512)
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| Co-Investigator(Renkei-kenkyūsha) |
NAMIKOSHI Michio 東北薬科大学, 薬学部, 教授 (30189196)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Keywords | ヒトデ / 自切 / NMDA受容体 |
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| Outline of Final Research Achievements |
Autotomy, the capacity to detach a body part, is a very characteristic defense mechanism in starfish. We identified the structure of the autotomy-promoting factor that induces autotomy: a 1:1 mixture of nicotinamide (NA) and N-methylquinolinic acid (NMQA). We characterized the molecular pathways of this process for the first time, using Asterias amurensis.
Inflammatory mechanism was related to 'slow autotomy'. Active compounds with protective neurodegeneration brought shortening of arm detachment time.
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| Free Research Field |
天然物化学
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