2014 Fiscal Year Final Research Report
Synthetic study of steroids utilizing biosynthesis
| Project/Area Number |
24510305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Keio University |
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Principal Investigator |
SHOJI MITSURU 慶應義塾大学, 薬学部, 准教授 (30339139)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | ステロイド / 天然物 / ドミノ環化 |
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| Outline of Final Research Achievements |
Steroids are widely distributed in nature and they have wide variety of bioactivities and unique polycyclic framework. In this study, the synthesis of the tetracyclic skeleton of steroids via manganese(III) and copper(II)-mediated radical polycyclization. Before starting the synthesis of tetracyclic structure, construction of tricyclic moiety was investigated. The cyclization precursor was prepared by convergent synthetic route. The domino cyclization proceeded to give the desired tricyclic product and the tetracyclic framework was also provided in the similar manner.
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| Free Research Field |
天然物化学、有機合成化学
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