2015 Fiscal Year Final Research Report
Drug discovery research: Searching for a new antibiotics based on stable phospho-histidine mimics
| Project/Area Number |
24510311
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Living organism molecular science
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| Research Institution | Nagasaki International University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Keitaro 長崎国際大学, 薬学部, 講師 (60446127)
HAGIMORI Masayori 長崎大学, 薬学部, 准教授 (40446125)
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| Research Collaborator |
KINO Toru
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Keywords | ホスホヒスチジン / ペプチドライブラリー / 抗菌活性 |
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| Outline of Final Research Achievements |
The purpose of this study was searching for potential new antibiotics targeting bacterial two-component signal transduction system. Our achievements, so far are following: 1) We established stereoselective and scalable amino acid synthesis based on Schoelkopf chemistry. 2) We prepared enough quantity of the phosphor-histidine mimic. 3) Synthetic method for peptides containing the mimic is established. 4) Deprotection protocol for generating free phophoric acid is invented. 5) Rapid and cheap synthesis method for dipeptide mimics is developed. Biological assay for antibiotic activities are still on going.
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| Free Research Field |
医薬品化学
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