Search for the antiausterity agents induced metabolomic biomarkers associated with the tolerance of nutrition starvation in pancreatic cancer

2015 Fiscal Year Final Research Report

• Project/Area Number: 24510314
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: University of Toyama
• Principal Investigator: Awale Suresh 富山大学, 和漢医薬学総合研究所, 准教授 (00377243)
• Co-Investigator(Renkei-kenkyūsha): ESUMI HIROYASU 東京理科大学, 生命医科学研究所, 教授 (70160364)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: Pancreatic cancer / PANC-1 / Antiausterity strategy / metabolomics / Biomarker / Drug Discovery

Outline of Final Research Achievements

Human pancreatic cancer cell lines, such as PANC-1 have altered metabolism, which enables them to tolerate and survive under the extreme nutrient starvation condition. Search for candidates that inhibit their viability during nutrition starvation represents a novel anti-austerity strategy in anticancer drug discovery. We investigated selected medicinal plants such as Uvaria dac, Caesalpinia sappan, Artocarpus altilis as a potential source for anti-austerity agents. A total of thirty-two new compounds were isolated. The mechanism of action of selected active anti-austerity agents was investigated by proteomic and metabolomic analysis.

Free Research Field

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