2014 Fiscal Year Final Research Report
Development of cell membrane penetrating peptides
| Project/Area Number |
24510317
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical biology
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| Research Institution | Nagahama Institute of Bio-Science and Technology |
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Principal Investigator |
HASEGAWA Makoto 長浜バイオ大学, バイオサイエンス学部, 教授 (10367899)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Keywords | バイオプローブ / 機能性ペプチド |
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| Outline of Final Research Achievements |
Artificial peptides designed for cell penetrating have been developed by using systematic directed evolution in vitro, a cDNA display method. A surface plasmon resonance-based biosensor and fluorescence correlation spectroscopy to examine binding of peptides to POPC with high affinity. This study describes a new strategy for the development of artificial functional peptides, which are promising materials in biochemical analyses and medical applications.
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| Free Research Field |
ケミカルバイオロジー
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