Development of anti-saccharide antibody screening system using glycosylated silsesquioxane probe.

2015 Fiscal Year Final Research Report

• Project/Area Number: 24510318
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: The Noguchi Institute
• Principal Investigator: Mizuno Mamoru 公益財団法人野口研究所, その他部局等, その他 (40271506)
• Co-Investigator(Kenkyū-buntansha): FUJITA Masaya 公益財団法人野口研究所, 研究部, 研究員 (20321672) ; KAWAKAMI Hiroko 公益財団法人野口研究所, 研究部, 研究員 (40320254) ; OSUMI Kenji 公益財団法人野口研究所, 研究部, 研究員 (90203778)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Keywords: 糖鎖抗体 / シルセスキオキサン / フルオラス

Outline of Final Research Achievements

The aim of this study is the development of a high-throughput anti-saccharide antibody screening system using a glycosylated silsesquioxane probe .
First, various investigations on the introduction of the oligosaccharide by thiol - ene reaction to the silsesquioxane (POSS) derivative were carried out to prepare a glycosylated silsesquioxane probe. But side-reaction proceeded preferentially, and it was found that the synthesis of sufficient amounts of desired product is very difficult.
Next, in order to introduce oligosaccharide moiety to POSS by amide bond, synthesis of protected POSS derivative only one place amino group was investigated, and preparation of the desired compound was succeeded.

Free Research Field

有機化学