Novel Affinity Screening System of PET Probe for Tau aggregates using Human Brain Tissue Microsection

2014 Fiscal Year Final Research Report

• Project/Area Number: 24510322
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: National Center for Geriatrics and Gerontology
• Principal Investigator: YOSHIMI Tatsuya 独立行政法人国立長寿医療研究センター, 治療薬探索研究部, 研究員 (30277256)
• Co-Investigator(Kenkyū-buntansha): OSAMU Takikawa 国立長寿医療研究センター, 治療薬探索研究部, 室長 (70163342)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Keywords: イメージング質量分析 / アルツハイマー病 / タウ / 創薬スクリーニング / 薬物動態 / PET化合物 / 神経変性疾患 / ロボットシステム

Outline of Final Research Achievements

We have developed a novel screening system for affinity chemical compounds visualizing a pathogenic protein, Tau, aggregates in human brain. This system uses tiny stainless microchips to make a number of small frozen brain sections, and imaging mass spectrometry is used for affinity selection of the chemicals. We have screened several affinity chemical compounds which have high affinity to Tau accumulated brain of Alzheimer's disease patient. The system will be useful on drug screening and kinetics analyses. The result will make a contribution to drug discovery and diagnosis of Alzheimer's disease.

Free Research Field

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